Research outputs, reports, policy briefs and knowledge products from KIU scholars and partners.
Knowledge Outputs
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2026 | NEWPORT INTERNATIONAL JOURNAL OF RESEARCH IN MEDICAL SCIENCES (NIJRMS) | Pp. 102-108
Obesity and type 2 diabetes (T2D) arise from complex, tissue-specific pathologies spanning adipose inflammation, ectopic lipid deposition, hepatic insulin resistance, and microvascular dysfunction. Conventional diagnostics detect late-stage complications and...
2026 | NEWPORT INTERNATIONAL JOURNAL OF RESEARCH IN MEDICAL SCIENCES (NIJRMS) | Pp. 59-66
Obesity and type 2 diabetes are heterogeneous, network-level disorders arising from the interplay of genetic variation, epigenetic remodeling, environmental exposures, and metabolic rewiring across adipose tissue, liver, skeletal muscle, gut, and pancreatic i...
2026 | NEWPORT INTERNATIONAL JOURNAL OF RESEARCH IN MEDICAL SCIENCES (NIJRMS) | Pp. 87-94
Obesity-associated type 2 diabetes (T2D) arises from chronic positive energy balance, adipose tissue dysfunction, low-grade inflammation, and insulin resistance. Converting energy-storing white adipose tissue into thermogenically active beige/brown–like adipo...
2026 | NEWPORT INTERNATIONAL JOURNAL OF RESEARCH IN MEDICAL SCIENCES (NIJRMS) | Pp. 95-101
Phytochemicals have long served as bioactive agents against metabolic disorders such as obesity and type 2 diabetes mellitus (T2DM). However, their poor solubility, instability, rapid metabolism, and low bioavailability hinder clinical efficacy. Nanotechnolog...
2026 | NEWPORT INTERNATIONAL JOURNAL OF RESEARCH IN MEDICAL SCIENCES (NIJRMS) | Pp. 81-86
Obesity and diabetes mellitus (DM) are interrelated global health crises, jointly termed diabesity, that arise from complex metabolic, genetic, and behavioral factors. Both conditions promote insulin resistance, oxidative stress, and systemic inflammation, pr...
2026 | NEWPORT INTERNATIONAL JOURNAL OF RESEARCH IN MEDICAL SCIENCES (NIJRMS) | Pp. 73-80
Obesity is increasingly understood as a brain-centric disorder in which hypothalamic circuits and the gut–brain axis fail to correctly integrate peripheral signals of energy status. Hypercaloric diets and adipose expansion drive leptin and insulin resistance,...
2026 | NEWPORT INTERNATIONAL JOURNAL OF RESEARCH IN MEDICAL SCIENCES (NIJRMS) | Pp. 67-72
Obesity imposes optical, vascular, metabolic, and pharmacokinetic constraints that blunt the performance of photothermal therapy and photodynamic therapy while exacerbating off-target toxicity. Enlarged adipose depots scatter and absorb light differently from...
2026 | NEWPORT INTERNATIONAL JOURNAL OF RESEARCH IN MEDICAL SCIENCES (NIJRMS) | Pp. 1-11
Obesity-linked type 2 diabetes (T2D) arises from chronic nutrient excess, ectopic lipid deposition, and unresolved inflammation that together blunt insulin signaling and exhaust β-cell function. Plant-derived antidiabetic compounds, flavonoids (quercetin, kae...
2026 | NEWPORT INTERNATIONAL JOURNAL OF RESEARCH IN MEDICAL SCIENCES (NIJRMS) | Pp. 48-52
Obesity is strongly linked to metabolic disorders such as type 2 diabetes, dyslipidemia, cardiovascular disease, and non-alcoholic fatty liver disease. Early detection of these complications is crucial for timely intervention, yet current diagnostic methods o...
2026 | NEWPORT INTERNATIONAL JOURNAL OF RESEARCH IN MEDICAL SCIENCES (NIJRMS) | Pp. 39-47
Obesity is a chronic, relapsing metabolic disease in which the gut microbiota plays a central regulatory role. Dysbiosis, impaired barrier integrity and altered microbial metabolites contribute to increased energy harvest, low-grade inflammation, insulin resi...