Research outputs, reports, policy briefs and knowledge products from KIU scholars and partners.
Knowledge Outputs
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2026 | NEWPORT INTERNATIONAL JOURNAL OF RESEARCH IN MEDICAL SCIENCES (NIJRMS) | Pp. 31-38
Obesity is characterized by chronic low-grade inflammation that originates primarily in expanding white adipose tissue and propagates to liver, skeletal muscle, vascular endothelium and pancreas, driving insulin resistance and cardiometabolic complications. H...
2026 | NEWPORT INTERNATIONAL JOURNAL OF PUBLIC HEALTH AND PHARMACY (NIJPP) | Pp. 95-100
Malaria remained a critical global health challenge, with Plasmodium falciparum causing approximately 229 million cases and 409,000 deaths annually, predominantly affecting sub-Saharan Africa. Traditional artemisinin-based combination therapies face mounting...
2026 | NEWPORT INTERNATIONAL JOURNAL OF RESEARCH IN MEDICAL SCIENCES (NIJRMS) | Pp. 25-30
Obesity-induced insulin resistance (IR) is a major contributor to the pathogenesis of type 2 diabetes (T2D) and is largely driven by chronic low-grade inflammation in adipose tissue. Adipose tissue inflammation not only impairs insulin signaling but also exac...
2026 | NEWPORT INTERNATIONAL JOURNAL OF RESEARCH IN MEDICAL SCIENCES (NIJRMS) | Pp. 19-21
Adipokines sit at the crossroads of metabolic status and cancer biology. In obesity, elevated leptin and reduced adiponectin converge with chronic low-grade inflammation to remodel the tumor microenvironment toward angiogenesis, immune evasion, fibrosis, and...
2026 | NEWPORT INTERNATIONAL JOURNAL OF RESEARCH IN MEDICAL SCIENCES (NIJRMS) | Pp. 12-18
The gut microbiome plays a critical role in regulating host metabolism, and emerging evidence suggests that dysbiosis, or an imbalance in microbial composition, is a key factor in the pathogenesis of obesity and type 2 diabetes (T2D). Modulating the gut micro...
2026 | NEWPORT INTERNATIONAL JOURNAL OF PUBLIC HEALTH AND PHARMACY (NIJPP) | Pp. 101-106
Malaria due to Plasmodium falciparum remains a major cause of morbidity and mortality, with an estimated 249 million cases and 608 000 deaths reported globally in 2022, and a high burden in sub–Saharan Africa. Artemisininbased combination therapies (ACTs) are...
2026 | NEWPORT INTERNATIONAL JOURNAL OF PUBLIC HEALTH AND PHARMACY (NIJPP) | Pp. 87-94
Obesity-driven type 2 diabetes (T2D) is sustained by chronic, low-grade inflammation that disrupts insulin signaling across adipose tissue, liver, skeletal muscle, and vascular beds. Hypertrophic adipocytes and stromal immune cells form an inflammatory niche...
2026 | NEWPORT INTERNATIONAL JOURNAL OF PUBLIC HEALTH AND PHARMACY (NIJPP) | Pp. 79-86
Adipose tissue and skeletal muscle are central endocrine organs that communicate through a complex network of secreted proteins, including adipokines and myokines, which shape systemic energy balance, insulin sensitivity and inflammation. In obesity and type...
2026 | NEWPORT INTERNATIONAL JOURNAL OF PUBLIC HEALTH AND PHARMACY (NIJPP) | Pp. 1-10
Phytochemicals such as polyphenols, terpenoids and alkaloids show robust anti-obesity activity in vitro and in animal models through modulation of adipogenesis, lipolysis, thermogenesis, inflammation, insulin signaling and gut microbiota. However, their trans...
2026 | NEWPORT INTERNATIONAL JOURNAL OF PUBLIC HEALTH AND PHARMACY (NIJPP) | Pp. 70-78
Obesity is driven by chronic energy surplus, sedentary lifestyles and environments that promote overconsumption of calorie-dense, nutrient-poor foods. Alongside pharmacotherapy and lifestyle interventions, functional foods enriched with bioactive nutraceutica...