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2026 School of Allied Health Sciences

Single-Cell and Spatial Omics for Prostate Cancer Stratification: Translational Pathways, Adoption Barriers, Implementation, and Equity Considerations

Nakalya Twamina T.

2026 | RESEARCH INVENTION JOURNAL OF PUBLIC HEALTH AND PHARMACY | Pp. 106-116

Prostate cancer (PCa) is characterized by pronounced molecular heterogeneity, complicating risk stratification and therapeutic decision-making. Recent advances in single-cell and spatial omics technologies enable high-resolution profiling of tumor and microen...

2026 Faculty of Clinical Medicine and Dentistry

Proteogenomics-Guided Risk-Based Screening for Coronary Artery Disease: Implementation across Diverse Populations and Equity Considerations

Obwendo N. J.

2026 | RESEARCH INVENTION JOURNAL OF PUBLIC HEALTH AND PHARMACY | Pp. 88-97

Coronary artery disease (CAD) remains the leading cause of global morbidity and mortality, necessitating more effective and equitable preventive strategies. Proteogenomics-guided risk-based screening integrates genomic variation, circulating protein biomarker...

2026 Faculty of Clinical Medicine and Dentistry

Precision Public Health Applications of Whole-Exome Sequencing for Sickle Cell Disease: Evidence, Equity, and Implementation Challenges from Bench to Population

Kagambira Zimbuga M.

2026 | RESEARCH INVENTION JOURNAL OF PUBLIC HEALTH AND PHARMACY | Pp. 82-87

Sickle cell disease (SCD) is a monogenic hematologic disorder that causes significant morbidity and mortality worldwide, disproportionately affecting populations of African, Indian, Middle Eastern, and Mediterranean ancestry. Whole-exome sequencing (WES) offe...

2026 Faculty of Clinical Medicine and Dentistry

Precision Public Health Applications of Polygenic Risk Scores for Alzheimer’s disease: Evidence, Equity, and Implementation Challenges

Bamuraza Nfukwe W.

2026 | RESEARCH INVENTION JOURNAL OF PUBLIC HEALTH AND PHARMACY | Pp. 74-81

Advances in genomic medicine have enabled the emergence of precision public health, with polygenic risk scores (PRS) offering novel tools for population-level risk stratification and intervention. Alzheimer’s disease (AD), the most prevalent neurodegenerative...

2026 Faculty of Clinical Medicine and Dentistry

Precision Public Health Applications of Liquid Biopsy Genomics for Colorectal Cancer: Evidence, Equity, and Implementation Challenges

Kintuza Lumwako Tebulo

2026 | RESEARCH INVENTION JOURNAL OF PUBLIC HEALTH AND PHARMACY | Pp. 70-73

Colorectal cancer (CRC) remains a leading cause of cancer morbidity and mortality worldwide, with early detection critical to improving outcomes. Liquid biopsy genomics offers a minimally invasive approach to detect tumor-derived analytes in biofluids, provid...

2026 Faculty of Clinical Medicine and Dentistry

Precision Public Health Applications of CRISPR-Based Diagnostics for Tuberculosis: Evidence, Equity, and Implementation Challenges

Nyiramana Mukamurera P.

2026 | RESEARCH INVENTION JOURNAL OF PUBLIC HEALTH AND PHARMACY | Pp. 62-69

Timely and accurate detection of Mycobacterium tuberculosis (Mtb) remains a cornerstone of global tuberculosis (TB) control. Traditional diagnostic tools face limitations, including delayed results, variable sensitivity, and restricted access in resource-limi...

2026 Faculty of Clinical Medicine and Dentistry

Population Genomics for Stroke: Return of Results, Cascade Testing, and Health System Readiness from Bench-to-Population Perspectives

Nyiramana Mukamurera P.

2026 | RESEARCH INVENTION JOURNAL OF PUBLIC HEALTH AND PHARMACY | Pp. 53-61

Stroke remains a leading cause of mortality and disability worldwide, with both monogenic and polygenic genetic determinants contributing to individual and population risk. Population genomics provides a transformative approach to understanding these genetic...

2026 School of Natural and Applied Sciences

Population Genomics for Familial Hypercholesterolemia: Return of Results, Cascade Testing, and Health System Readiness, Current Evidence and Gaps

Kamanzi Ntakirutimana G.

2026 | RESEARCH INVENTION JOURNAL OF PUBLIC HEALTH AND PHARMACY | Pp. 46-52

Familial hypercholesterolemia (FH) is a common inherited lipid disorder associated with markedly elevated cholesterol levels and a substantially increased risk of premature cardiovascular disease. Advances in population genomics, including biobank sequencing,...

2026 School of Natural and Applied Sciences

Polygenic Risk Scores for Type 2 Diabetes in South Asian Populations: Transferability, Calibration, and Decision Thresholds

Kamanzi Ntakirutimana G.

2026 | RESEARCH INVENTION JOURNAL OF PUBLIC HEALTH AND PHARMACY | Pp. 38-45

Polygenic risk scores (PRS) are increasingly used to estimate genetic susceptibility to complex diseases such as type 2 diabetes (T2D). However, most PRS models are derived from genome-wide association studies conducted primarily in European populations, rais...

2026 School of Natural and Applied Sciences

Pharmacogenomics using Whole-Exome Sequencing in Oncology Clinics: Clinical Workflows, Outcomes, and Cost-Effectiveness

Nyambura Achieng M.

2026 | RESEARCH INVENTION JOURNAL OF PUBLIC HEALTH AND PHARMACY | Pp. 30-37

Pharmacogenomics leverages genomic information to optimize drug therapy, improving efficacy and minimizing toxicity in oncology patients. Whole-exome sequencing (WES) provides a comprehensive platform for identifying clinically actionable variants in germline...