Research outputs, reports, policy briefs and knowledge products from KIU scholars and partners.
Knowledge Outputs
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2026 | RESEARCH INVENTION JOURNAL OF RESEARCH IN MEDICAL SCIENCES | Pp. 42-49
Obesity-driven type 2 diabetes (T2D) is increasingly recognized as a chronic disorder of “metabolic memory” (MM), in which prior exposure to obesogenic and hyperglycemic milieus leaves long-lasting molecular scars that sustain insulin resistance, β-cell dysfu...
2026 | RESEARCH INVENTION JOURNAL OF RESEARCH IN MEDICAL SCIENCES | Pp. 38-41
The ongoing HIV epidemic disproportionately affected adolescent and young adult populations worldwide, underscoring the urgent need for effective prevention strategies. Long-acting injectable cabotegravir (CAB-LA) has emerged as a novel pre-exposure prophylax...
2026 | RESEARCH INVENTION JOURNAL OF RESEARCH IN MEDICAL SCIENCES | Pp. 31-37
Human immunodeficiency virus (HIV) remained a global public health challenge despite advances in antiretroviral therapy. Oral pre-exposure prophylaxis with tenofovir-based regimens has demonstrated efficacy but faces adherence barriers that limit real-world e...
2026 | RESEARCH INVENTION JOURNAL OF RESEARCH IN MEDICAL SCIENCES | Pp. 24-30
Human immunodeficiency virus pre-exposure prophylaxis had traditionally relied on daily oral tenofovir-based regimens, which demonstrated high efficacy when adherence is maintained but face substantial implementation challenges related to daily pill burden, s...
2026 | RESEARCH INVENTION JOURNAL OF RESEARCH IN MEDICAL SCIENCES | Pp. 9-17
Obesity-linked type 2 diabetes is driven by chronic insulin resistance coupled to progressive dysfunction and loss of pancreatic β-cells. Standard glucose-lowering therapies improve glycemia but either protect β-cells only indirectly or require high systemic...
2026 | RESEARCH INVENTION JOURNAL OF RESEARCH IN MEDICAL SCIENCES | Pp. 1-8
Obesity is characterized by chronic energy surplus, hypertrophic and hyperplastic expansion of white adipose tissue, ectopic lipid deposition and complex disturbances in lipid and glucose metabolism. Pharmacologic approaches that directly modulate adipogenesi...
2026 | RESEARCH INVENTION JOURNAL OF RESEARCH IN MEDICAL SCIENCES | Pp. 18-23
Lipid metabolism and glucose homeostasis are two intertwined metabolic processes that are often dysregulated in conditions such as obesity, insulin resistance, and type 2 diabetes (T2D). Given the complexity of these disorders, therapeutic strategies targetin...
2026 | RESEARCH INVENTION JOURNAL OF SCIENTIFIC AND EXPERIMENTAL SCIENCES | Pp. 109-113
Oxidative stress and inflammation are interconnected biological processes that underlie the pathogenesis of many chronic and infectious diseases. In malaria, diabetes, and arthritis, the imbalance between reactive oxygen species (ROS) generation and antioxida...
2026 | RESEARCH INVENTION JOURNAL OF SCIENTIFIC AND EXPERIMENTAL SCIENCES | Pp. 101-108
Obesity-induced type 2 diabetes (T2D) is not simply a problem of “too much fat” but of where lipid ends up and how it moves between organs. Under physiological conditions, subcutaneous adipose tissue (AT) serves as a safe reservoir that buffers postprandial l...
2026 | RESEARCH INVENTION JOURNAL OF SCIENTIFIC AND EXPERIMENTAL SCIENCES | Pp. 97-100
Chronic inflammatory conditions such as rheumatoid arthritis, lupus, and asthma often require long-term management with corticosteroids to control inflammation and prevent tissue damage. However, the prolonged use of steroids is associated with numerous adver...