Research outputs, reports, policy briefs and knowledge products from KIU scholars and partners.
Knowledge Outputs
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2026 | RESEARCH INVENTION JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES | Pp. 111-120
Insecticide-treated bed nets represented a cornerstone intervention in malaria vector control, contributing significantly to reduced transmission across endemic regions. However, widespread pyrethroid resistance in Anopheles mosquito populations threatened to...
2026 | RESEARCH INVENTION JOURNAL OF SCIENTIFIC AND EXPERIMENTAL SCIENCES | Pp. 8-12
Arthritis is a leading cause of chronic pain, disability, and reduced quality of life globally, with West Africa facing significant challenges in early diagnosis and effective management. Limited healthcare infrastructure, shortage of trained personnel, and l...
2026 | RESEARCH INVENTION JOURNAL OF SCIENTIFIC AND EXPERIMENTAL SCIENCES | Pp. 1-7
Despite effective antiretroviral therapy, people living with HIV harbored a latent viral reservoir in long-lived memory CD4+ T cells that prevents cure. Immune checkpoint molecules, initially recognized for their role in maintaining peripheral tolerance and p...
2026 | RESEARCH INVENTION JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES | Pp. 102-110
Human immunodeficiency virus (HIV) persisted in latent reservoirs despite effective antiretroviral therapy (ART), presenting the primary barrier to achieving a functional cure. Immune checkpoint inhibitors (ICIs), originally developed for cancer immunotherapy...
2026 | RESEARCH INVENTION JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES | Pp. 31-37
Severe malaria, predominantly caused by Plasmodium falciparum, progresses unpredictably from uncomplicated infection to life-threatening complications, including cerebral malaria, severe anemia, and metabolic acidosis. Immune responses varied substantially be...
2026 | RESEARCH INVENTION JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES | Pp. 94-101
Plasmodium infection triggered profound alterations in host metabolic pathways affecting glucose metabolism, lipid homeostasis, amino acid catabolism, and mitochondrial function across multiple organ systems. These metabolic perturbations represented adaptive...
2026 | RESEARCH INVENTION JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES | Pp. 87-93
Plasmodium falciparum infection triggered complex host immune responses that determined disease severity, with cerebral malaria representing the most lethal complication characterized by profound neuroinflammation, endothelial dysfunction, and blood-brain bar...
2026 | RESEARCH INVENTION JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES | Pp. 38-42
Type 2 diabetes mellitus (T2DM) was characterized by impaired glucose homeostasis and insulin resistance, necessitating pharmacologic interventions to maintain glycemic control. Sulfonylureas (SUs) had been widely used to stimulate insulin secretion but were...
2026 | RESEARCH INVENTION JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES | Pp. 8-12
Metabolic disorders such as diabetes mellitus are frequently associated with serious hepatic and renal complications that contribute significantly to morbidity and mortality. The underlying mechanisms involve complex interactions among hyperglycemia, dyslipid...
2026 | RESEARCH INVENTION JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES | Pp. 63-67
Whole-genome sequencing (WGS) has rapidly transitioned from specialized research laboratories to the direct-toconsumer (DTC) genetic testing marketplace due to declining costs and advances in high-throughput sequencing technologies. While these services expan...