Publications

2026 School of Pharmacy

Ethical, Legal, and Social Implications of Whole-Exome Sequencing in Biobank Initiatives: Consent, Governance, and Trust Methods, Challenges, and Future Directions

Twesigye Davis

2026 | RESEARCH INVENTION JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES | Pp. 43-52

Whole-exome sequencing (WES) in biobank initiatives has emerged as a transformative tool for advancing genomic research and precision medicine. By capturing all protein-coding regions of the human genome, WES enables the identification of genetic variants tha...

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2026 School of Pharmacy

Ethical, Legal, and Social Implications of Single-Cell Transcriptomics in Public Health Surveillance: Consent, Governance, Trust Implementation, and Equity Considerations

Ivan Mutebi

2026 | RESEARCH INVENTION JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES | Pp. 21-30

Single-cell transcriptomics is emerging as a powerful tool for public health surveillance, enabling high-resolution detection of pathogen activity, host responses, and environmental biological signals at unprecedented spatial and temporal scales. While this t...

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2026 School of Pharmacy

Ethical, Legal, and Social Implications of Metabolomics in Low and Middle-Income Countries: Consent, Governance, and Trust

Ivan Mutebi

2026 | RESEARCH INVENTION JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES | Pp. 77-86

Metabolomics, the comprehensive analysis of small-molecule metabolites in biological samples, offers significant potential to improve health outcomes and support sustainable development in low- and middle-income countries (LMICs). However, its implementation...

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2026 School of Pharmacy

Clinical Validity and Utility of Whole-Genome Sequencing In Rare Mendelian Disorders: Lessons for Population Screening and Policy

Ivan Mutebi

2026 | RESEARCH INVENTION JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES | Pp. 53-62

Whole-genome sequencing (WGS) has emerged as a powerful genomic tool for diagnosing rare Mendelian disorders, offering substantial gains in clinical validity and clinical utility compared with traditional single-gene or panel-based approaches. By simultaneous...

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2026 School of Pharmacy

Clinical Validity and Utility of Multi-Omic Risk Scores in Type 2 Diabetes: Implications for Population Screening and Policy

Ivan Mutebi

2026 | RESEARCH INVENTION JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES | Pp. 68-76

Type 2 diabetes (T2D) represents a growing global health challenge, with early detection of at-risk individuals being critical for prevention and management. Traditional risk factors and biomarkers, while informative, have limited predictive accuracy, particu...

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2026 School of Pharmacy

Clinical Validity and Utility of Long-Read Sequencing in Sickle Cell Disease: Lessons for Population Screening and Policy

Kungu Erisa

2026 | RESEARCH INVENTION JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES | Pp. 13-20

Sickle cell disease (SCD) is a prevalent monogenic disorder with significant morbidity and mortality worldwide, particularly in low- and middle-income countries. Early diagnosis through population screening is critical to reduce adverse health outcomes and en...

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2026 School of Pharmacy

Clinical Validity and Utility of CRISPR-Based Diagnostics in HIV: Lessons for Population Screening and Policy Methods, Challenges, and Future Directions

Kungu Erisa

2026 | RESEARCH INVENTION JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES | Pp. 1-7

CRISPR-based diagnostics represent a promising innovation in the detection of human immunodeficiency virus (HIV), with potential to improve early diagnosis, expand population screening, and strengthen public health responses. This paper examines the clinical...

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2026 Faculty of Clinical Medicine and Dentistry

Therapeutic Antioxidants and the Immune Response: Mechanistic Interactions and Clinical Implications

Kansiime Agnes

2026 | IAA Journal of Applied Sciences | Pp. 44-48

Therapeutic antioxidants have emerged as promising modulators of immune function by mitigating oxidative stress and influencing inflammatory pathways. Reactive oxygen species (ROS), when produced in excess, can damage cellular components including DNA, lipids...

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2026 Faculty of Clinical Medicine and Dentistry

The Interplay of Insulin Resistance, Inflammation, and Antioxidant Depletion in Diabetes: A Comprehensive Review

Chelimo Faith Rebecca

2026 | IAA Journal of Applied Sciences | Pp. 30-35

Diabetes mellitus arises through a multifaceted network of metabolic derangements, prominently featuring insulin resistance, chronic inflammation, and oxidative stress. These three processes do not occur in isolation; rather, they form a self-reinforcing tria...

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2026 School of Natural and Applied Sciences

Rheumatoid Factor Beyond Rheumatoid Arthritis: Metabolic and Immunologic Implications in Diabetes Mellitus

Mugo Moses H.

2026 | IAA Journal of Applied Sciences | Pp. 6-11

Rheumatoid factor (RF), a classic autoantibody directed against the Fc portion of immunoglobulin G (IgG), has long been recognized as a hallmark of rheumatoid arthritis (RA). However, emerging evidence indicates that RF positivity extends far beyond rheumatol...

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