Research outputs, reports, policy briefs and knowledge products from KIU scholars and partners.
Knowledge Outputs
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2026 | IAA Journal of Biological Sciences | Pp. 133-141
Population genomics is reshaping breast cancer prevention by enabling the identification of individuals and families at elevated genetic risk before disease onset. Advances in genomic technologies have made populationscale screening for high-penetrance breast...
2026 | IAA Journal of Biological Sciences | Pp. 125-132
Polygenic risk scores (PRS) have emerged as promising tools for stratifying breast cancer risk and informing screening and prevention strategies. However, their clinical utility in African ancestry populations remains limited due to poor transferability, misc...
2026 | IAA Journal of Applied Sciences | Pp. 18-23
Oxidative stress is a defining molecular hallmark of diabetes mellitus and its complications. Both type 1 and type 2 diabetes are characterized by excessive production of reactive oxygen species (ROS), chronic low-grade inflammation, mitochondrial dysfunction...
2026 | IAA Journal of Biological Sciences | Pp. 114-124
Newborn screening is a cornerstone of preventive public health, enabling the early identification of congenital and metabolic disorders for which timely intervention can substantially reduce morbidity and mortality. Advances in metabolomics now present an opp...
2026 | IAA Journal of Applied Sciences | Pp. 36-43
Mitochondrial dysfunction has emerged as a central mechanism linking metabolic derangements, immune dysregulation, and multi-organ toxicity in Type 2 Diabetes Mellitus (T2DM). Beyond its classical features of insulin resistance and hyperglycaemia, T2DM is cha...
2026 | IAA Journal of Biological Sciences | Pp. 87-97
Ischemic stroke remains a leading cause of mortality and long-term disability worldwide, with risk prediction constrained by incomplete characterization of biological heterogeneity and limited integration of high-dimensional data. Advances in long-read genomi...
2026 | IAA Journal of Applied Sciences | Pp. 24-29
Hyperglycaemia is a defining biochemical hallmark of diabetes mellitus and exerts profound effects on cellular redox homeostasis and immune function. Sustained elevations in blood glucose promote excessive generation of reactive oxygen species (ROS) through m...
2026 | IAA Journal of Biological Sciences | Pp. 82-86
The gut microbiota plays a crucial role in maintaining metabolic homeostasis and influencing the development of obesity and type 2 diabetes (T2D). Dysbiosis, an imbalance in gut microbial composition, has been linked to insulin resistance, inflammation, and d...
2026 | IAA Journal of Biological Sciences | Pp. 75-81
Bile acids (BAs) have emerged as pleiotropic signaling molecules that connect gut microbiota, liver, intestine, and peripheral metabolic tissues. Beyond their classical role in lipid absorption, BAs act as endocrine regulators via receptors such as the farnes...
2026 | IAA Journal of Biological Sciences | Pp. 60-64
Type 1 diabetes mellitus was characterized by autoimmune destruction of pancreatic beta cells, leading to absolute insulin deficiency and lifelong dependence on exogenous insulin therapy. Emerging evidence suggested that glucagon signaling contributed to hype...