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2026 School of Pharmacy

CRISPR-Based Gene Drive Technology for Anopheles Mosquito Population Suppression in Malaria Control

Twesigye Davis

2026 | IAA Journal of Applied Sciences | Pp. 115-118

Malaria, primarily transmitted by Anopheles mosquitoes, continued to exact a heavy toll worldwide. Traditional vector control methods face challenges such as insecticide resistance, necessitating novel, sustainable interventions. CRISPR-based gene drive techn...

2026 School of Pharmacy

CRISPR-Cas9 CCR5 Gene Editing for Functional Cure in HIV Infected Individuals

Mpora Kakwanzi Evelyn

2026 | IAA Journal of Applied Sciences | Pp. 1-5

HIV persistence within latent reservoirs represents the principal barrier to cure despite lifelong antiretroviral therapy (ART). The CCR5 gene encodes a co-receptor essential for HIV-1 entry into CD4⁺ T cells, and individuals homozygous for the CCR5-Δ32 mutat...

2026 School of Pharmacy

Comparing Diarrhea Incidence in Low- and High-Income Urban Neighborhoods

Ivan Mutebi

2026 | IAA Journal of Applied Sciences | Pp. 110-114

Diarrheal diseases remain a leading cause of morbidity and mortality in urban populations, particularly among children under five, with a disproportionate burden in low-income neighborhoods. This review examines the incidence of diarrhea across low- and high-...

2026 School of Pharmacy

Comparative Cost-Effectiveness of Typhoid Vaccination and Treatment in Rural vs. Urban Ugandan Healthcare Settings

Ivan Mutebi

2026 | IAA Journal of Applied Sciences | Pp. 105-109

Typhoid fever remains a major public health challenge in Uganda, particularly in communities where sanitation, water quality, and healthcare access are inadequate. Despite the availability of effective vaccines and antibiotics, disparities in healthcare infra...

2026 School of Pharmacy

Community-Based Intermittent Preventive Treatment Efficacy in Pregnant Women Across Sub-Saharan African Settings

Kungu Erisa

2026 | IAA Journal of Applied Sciences | Pp. 98-104

Malaria during pregnancy posed substantial risks to maternal and fetal health in sub-Saharan Africa, contributing to maternal anemia, placental parasitemia, low birth weight, and neonatal mortality. Intermittent preventive treatment in pregnancy with sulfadox...

2026 School of Pharmacy

Combined Chemical Exposures and Synergistic Toxicity: Unraveling Biochemical Interactions in the Anthropocene

Kungu Erisa

2026 | IAA Journal of Applied Sciences | Pp. 90-97

Human and ecological systems in the Anthropocene are exposed to complex mixtures of chemicals from industrial, agricultural, pharmaceutical, and consumer-product sources. These combined exposures frequently produce effects that are not predicted by single-che...

2026 Faculty of Clinical Medicine and Dentistry

Closed-Loop Insulin Delivery Systems in Type 1 Diabetes: Technology Advances and Outcomes

Nagawa Jackline Irene

2026 | IAA Journal of Applied Sciences | Pp. 84-89

Type 1 diabetes mellitus was characterized by absolute insulin deficiency requiring lifelong exogenous insulin replacement. Traditional insulin delivery methods, including multiple daily injections and conventional insulin pumps, impose substantial burdens on...

2026 Faculty of Clinical Medicine and Dentistry

Clinical Validity and Utility of Epigenomic Profiling in Breast Cancer: Lessons for Population Screening and Policy

Nagawa Jackline Irene

2026 | IAA Journal of Applied Sciences | Pp. 79-83

Breast cancer risk is shaped not only by inherited genetic variation but also by dynamic and potentially reversible epigenomic modifications that reflect environmental exposures, ageing, and life-course influences. Epigenomic profiling, particularly DNA methy...

2026 Faculty of Clinical Medicine and Dentistry

Circadian Rhythm Disruption, Sleep Disorders, and Their Role in Obesity-Linked Diabetes

Abner Tom Kalukusu

2026 | IAA Journal of Applied Sciences | Pp. 72-78

Circadian timekeeping aligns cellular metabolism with daily cycles of light, feeding, and activity. In obesity-linked type 2 diabetes (T2D), misalignment between endogenous clocks and behavior via shift work, social jetlag, evening eating, short/fragmented sl...

2026 Faculty of Clinical Medicine and Dentistry

Circadian Rhythm Disruption as a Convergence Point for Obesity and Diabetes Pathogenesis

Asiimawe Masika Agnovia

2026 | IAA Journal of Applied Sciences | Pp. 65-71

Circadian rhythms orchestrate 24-hour cycles in behavior and physiology that are fundamental to metabolic homeostasis. A central clock in the suprachiasmatic nucleus and peripheral clocks in liver, adipose tissue, skeletal muscle, pancreas, and gut coordinate...