Publications

2024 Faculty of Clinical Medicine and Dentistry

Assessing Healthcare Workers' Knowledge, Practices, and Attitudes towards Snakebite Management: Implications for Public Health in Hoima regional Referral Hospital, Hoima District

Mumbere Derick

2024 | EURASIAN EXPERIMENT JOURNAL OF PUBLIC HEALTH | Pp. 41-54

The purpose of this study was to evaluate the knowledge, attitudes, and behaviours of healthcare professionals working inthe surgical ward and accident and emergency departments of Hoima Regional Referral Hospital in the Hoima Districtregarding the management...

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2024 School of Pharmacy

Antibacterial Potential and Phytochemical Analysis of Momordica foetida Extracts: A Prospective Study

Okiring Emmanuel Omieke

2024 | IDOSR JOURNAL OF BIOCHEMISTRY, BIOTECHNOLOGY AND ALLIED FIELDS | Pp. 7-14

Momordica foetida, a medicinal plant from the Cucurbitaceae family, has been traditionally used across tropicalAfrica for its therapeutic properties. This study aimed to evaluate the antibacterial effects of extracts fromdifferent parts of Momordica foetida (...

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2024 School of Allied Health Sciences

GATA-1 as a Modulator of Immune Responses in HIV-Infected Individuals: Implications for Disease Pathogenesis and Therapeutic Interventions

Emmanuel Ifeanyi Obeagu1 and Getrude Uzoma Obeagu2

2024 | Elite Journal of Laboratory Medicine | Pp. 57-74

GATA-1, known primarily for its role in hematopoiesis, has emerged as a critical modulator of immune responses in Human Immunodeficiency Virus (HIV)-infected individuals. This review explores the multifaceted role of GATA-1 in modulating immune responses duri...

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2024 School of Allied Health Sciences

Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) Blockade and HIV-Associated Kaposi Sarcoma: A Promising Therapeutic Strategy

*Emmanuel Ifeanyi Obeagu1 and Getrude Uzoma Obeagu2

2024 | Elite Journal of Scientific Research and Review | Pp. 78-94

Kaposi sarcoma (KS) remains a significant oncologic complication of HIV infection, particularly in regions with high HIV prevalence. Despite advances in antiretroviral therapy (ART), the incidence of KS remains elevated among HIV-infected individuals, highlig...

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2024 School of Allied Health Sciences

Immunodeficiency and Immune Reconstitution in Pediatric HIV: Mechanisms, Challenges, and Therapeutic Strategies

*Emmanuel Ifeanyi Obeagu1 and Getrude Uzoma Obeagu2

2024 | Elite Journal of Immunology | Pp. 62-79

Pediatric HIV infection poses unique challenges to the developing immune system, leading to profound immunodeficiency and impaired immune reconstitution despite antiretroviral therapy (ART). This review examines the mechanisms underlying immunodeficiency and...

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2024 School of Allied Health Sciences

GATA-1 and Bone Marrow Failure Syndromes in the Context of HIV Infection: A Review of Molecular Mechanisms and Therapeutic Implications

Emmanuel Ifeanyi Obeagu1 and Getrude Uzoma Obeagu2

2024 | Elite Journal of Laboratory Medicine | Pp. 39-56

Bone marrow failure syndromes, characterized by impaired hematopoiesis leading to cytopenias, represent significant complications in individuals living with HIV infection. GATA-1, a master transcription factor crucial for hematopoietic development, has emerge...

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2024 School of Allied Health Sciences

Programmed Cell Death Protein 1 (PD-1) Signaling in HIV-Associated Cardiovascular Disease: Mechanisms and Therapeutic Implications

*Emmanuel Ifeanyi Obeagu1 and Getrude Uzoma Obeagu2

2024 | Elite Journal of Scientific Research and Review | Pp. 61-77

Cardiovascular disease (CVD) remains a significant cause of morbidity and mortality in individuals living with HIV/AIDS, despite effective antiretroviral therapy (ART). Emerging evidence suggests a complex interplay between chronic inflammation, immune dysreg...

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2024 School of Allied Health Sciences

HIV-Induced Immune Exhaustion in Neonates: A Review of Mechanisms and Implications

Emmanuel Ifeanyi Obeagu1 and Getrude Uzoma Obeagu2

2024 | Elite Journal of Immunology. | Pp. 45-61

HIV infection during early life poses unique challenges to neonatal immune development, potentially leading to immune exhaustion and increased susceptibility to infections. This review explores the mechanisms and implications of HIV-induced immune exhaustion...

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2024 School of Allied Health Sciences

Programmed Cell Death Protein 1 (PD-1) Pathway Modulation in HIV/AIDS: From Bench to Bedside

Emmanuel Ifeanyi Obeagu1 and Getrude Uzoma Obeagu2

2024 | Elite Journal of HIV | Pp. 35-53

The programmed cell death protein 1 (PD-1) pathway plays a pivotal role in immune regulation and tolerance. In the context of HIV/AIDS, dysregulation of the PD-1 pathway contributes to T-cell exhaustion, immune dysfunction, and disease progression. This revie...

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2024 School of Allied Health Sciences

GATA-1 and Hematopoietic Stem Cell Maintenance in HIV: Mechanisms and Implications

*Emmanuel Ifeanyi Obeagu1 and Getrude Uzoma Obeagu2

2024 | Elite Journal of Health Sciences | Pp. 24-40

Hematopoietic stem cells (HSCs) are pivotal for maintaining blood cell production and immune function, and their dysregulation is implicated in hematological abnormalities observed in Human Immunodeficiency Virus (HIV) infection. GATA-1, a master transcriptio...

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