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5,279 results found Records are sourced from the KIU Publications module.
2025 School of Pharmacy

CRISPR-Based Gene Editing Approaches for Monogenic Diabetes Therapy and Precision Medicine

Namirimu Sandrah

2025 | IDOSR JOURNAL OF APPLIED SCIENCES | Pp. 53-58

Monogenic diabetes represents approximately 1-5% of all diabetes cases globally, with mutations in over 40 genes causing various forms of maturity onset diabetes of the young (MODY) and neonatal diabetes mellitus. The emergence of clustered regularly interspa...

2025 School of Pharmacy

Comparative Cost-Effectiveness of Typhoid Vaccination and Treatment in Rural vs. Urban Ugandan Healthcare Settings

Waiswa Arajab

2025 | IDOSR JOURNAL OF APPLIED SCIENCES | Pp. 47-52

Typhoid fever remains a persistent public health challenge in Uganda, with both urban and rural populations experiencing high disease and economic burdens. While antimicrobial treatment has historically been the mainstay of management, rising antimicrobial re...

2025 Faculty of Biomedical Sciences

Community-Based HIV Pre-Exposure Prophylaxis Implementation in Sub-Saharan Africa: A Review

Atukunda Derrick

2025 | IDOSR JOURNAL OF APPLIED SCIENCES | Pp. 43-46

Human immunodeficiency virus (HIV) remains a significant public health challenge in sub-Saharan Africa, where the region continued to account for nearly two-thirds of the global disease burden. Although antiretroviral therapy had transformed outcomes, the inc...

2025 School of Pharmacy

Community Health Worker Malaria Case Management in Rural Sub-Saharan Africa

Waiswa Arajab

2025 | IDOSR JOURNAL OF APPLIED SCIENCES | Pp. 39-42

Malaria remained one of the most pressing public health challenges in sub-Saharan Africa, where over 90% of global cases and deaths occur annually. Timely diagnosis and effective treatment were essential for reducing mortality and curbing transmission, yet he...

2025 Faculty of Biomedical Sciences

Circadian Rhythm and Chrononutrition in Glycemic Regulation: A Mini Review IDOSR JOURNAL OF

Atukunda Derrick

2025 | IDOSR JOURNAL OF APPLIED SCIENCES | Pp. 33-38

The circadian rhythm governs essential physiological processes, including glucose metabolism, insulin secretion, and energy homeostasis. Emerging research reveals that disruptions in circadian rhythms, whether due to shift work, sleep disturbances, or irregul...

2025 School of Pharmacy

CD4+ T Cell Exhaustion Biomarkers in Chronic HIV Infection: Prognostic Implications

Mangen Joshua Fred

2025 | IDOSR JOURNAL OF APPLIED SCIENCES | Pp. 29-32

Chronic human immunodeficiency virus (HIV) infection was characterized by progressive immune dysfunction, in which CD4+ T cell depletion and exhaustion play pivotal roles. CD4+ T cell exhaustion, marked by impaired proliferative capacity and sustained express...

2025 School of Pharmacy

Beta-Cell Regeneration and Stem-Cell-Derived Islet Transplantation

Mangen Joshua Fred

2025 | IDOSR JOURNAL OF APPLIED SCIENCES | Pp. 16-22

Diabetes mellitus, particularly type 1 diabetes (T1D), results from a loss or dysfunction of insulin-producing pancreatic β-cells. Restoration of β-cell mass and function remains a major therapeutic goal. Two complementary strategies hold promise: endogenous...

2025 School of Pharmacy

Beta Cell Autoantibody Profiles in Type 1 Diabetes: Predictive Biomarkers for Progression

Nakawungu Catherine

2025 | IDOSR JOURNAL OF APPLIED SCIENCES | Pp. 10-15

Type 1 diabetes represents a complex autoimmune disorder characterized by progressive beta cell destruction, affecting approximately 1.1 million children and adolescents globally with an increasing incidence of 3-4% annually. Beta cell autoantibodies served a...

2025 School of Pharmacy

Airway Microbiome in Respiratory Diseases

Mangen Joshua Fred

2025 | IDOSR JOURNAL OF APPLIED SCIENCES | Pp. 1-9

The airway microbiome is a dynamic and diverse ecosystem of bacteria, viruses, and fungi that contributes critically to respiratory health and disease. In health, microbial communities maintain homeostasis through interactions with epithelial barriers and hos...

2025 Faculty of Education

Engineering Strategies for Health Education and Promotion

Lubega Mohammed

2025 | IDOSR JOURNAL OF ARTS AND HUMANITIES | Pp. 41-47

Health education and promotion have evolved from didactic, paternalistic practices to participatory, empowerment-driven processes that emphasize community agency and interdisciplinary collaboration. Engineering, with its problem-solving orientation and innova...