Research outputs, reports, policy briefs and knowledge products from KIU scholars and partners.
Knowledge Outputs
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2025 | IDOSR JOURNAL OF SCIENTIFIC RESEARCH | Pp. 90-95
Natural compounds such as polyphenols, flavonoids, alkaloids, terpenoids, and saponins demonstrate significant anti-obesity potential by regulating adipogenesis, lipolysis, appetite, and energy expenditure. However, their clinical application is limited by po...
2025 | IDOSR JOURNAL OF SCIENTIFIC RESEARCH | Pp. 82-89
Obesity-associated diabetes (largely type 2 diabetes mellitus, T2DM) is a global public-health challenge driven by rising prevalence of obesity and metabolic dysfunction. Early diagnosis and continuous metabolic monitoring are essential to prevent complicatio...
2025 | IDOSR JOURNAL OF SCIENTIFIC RESEARCH | Pp. 73-81
Cancer immunotherapy has transformed oncology, yet clinical outcomes remain highly variable among patients. Emerging evidence highlights the microbiome as a critical determinant of therapeutic efficacy and toxicity. Microbial communities influence tumor progr...
2025 | IDOSR JOURNAL OF SCIENTIFIC RESEARCH | Pp. 62-72
The microbiome is a complex and dynamic ecosystem that contributes to host metabolism, immunity, and disease resistance. Infections represent major perturbations to this system, often disrupting microbial composition, diversity, and function. The resilience o...
2025 | IDOSR JOURNAL OF SCIENTIFIC RESEARCH | Pp. 51-61
The maternal and infant microbiomes play pivotal roles in pregnancy outcomes, immune maturation, and early childhood development. Traditionally, the fetus was thought to develop in a sterile environment; however, evidence now suggests that maternal microbial...
2025 | IDOSR JOURNAL OF SCIENTIFIC RESEARCH | Pp. 42-50
The intestinal microbiome plays a central role in the pathogenesis of inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis. Dysbiosis, characterized by reduced microbial diversity, expansion of pro-inflammatory taxa, and dep...
2025 | IDOSR JOURNAL OF SCIENTIFIC RESEARCH | Pp. 35-41
The human microbiome plays a critical role in drug metabolism, influencing both pharmacokinetics and pharmacodynamics, with significant implications for therapeutic efficacy and safety. Microorganisms in the gut, including bacteria, archaea, fungi, and viruse...
2025 | IDOSR JOURNAL OF SCIENTIFIC RESEARCH | Pp. 19-23
Malaria remains a global health challenge, with over 200 million cases annually, particularly affecting sub-Saharan Africa. The disease is caused by Plasmodium parasites, primarily P. falciparum, and transmitted via female Anopheles mosquitoes. A central fact...
2025 | IDOSR JOURNAL OF SCIENTIFIC RESEARCH | Pp. 1-6
The liver and kidney are critical organs responsible for metabolism, detoxification, and excretion, making them highly susceptible to toxic injury. Hepatotoxicity and nephrotoxicity arise from diverse insults, including xenobiotics, drugs, environmental chemi...
2025 | IDOSR JOURNAL OF APPLIED SCIENCES | Pp. 77-81
Despite sustained viral suppression achieved through antiretroviral therapy (ART), HIV persists in latently infected cells, forming proviral reservoirs that remain the principal barrier to cure. Latency reversing agents (LRAs) and CRISPR-Cas9 gene editing are...