Research outputs, reports, policy briefs and knowledge products from KIU scholars and partners.
Knowledge Outputs
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2025 | IDOSR JOURNAL OF EXPERIMENTAL SCIENCES | Pp. 99-108
Metabolic syndrome, a cluster of interconnected metabolic disturbances including obesity, insulin resistance, dyslipidemia, and hypertension, represents a major global health challenge. Current therapeutic strategies often target individual components of the...
2025 | IDOSR JOURNAL OF APPLIED SCIENCES | Pp. 23-28
The gut–brain–gonadal (GBG) axis represents a complex bidirectional network integrating endocrine, neural, and immune signals to regulate homeostasis. Emerging evidence indicates that dysregulation of reproductive hormones, such as estrogens, progesterone, an...
2025 | IDOSR JOURNAL OF EXPERIMENTAL SCIENCES | Pp. 89-98
Obesity-induced type 2 diabetes (T2D) is a complex metabolic disorder characterized by insulin resistance and chronic low-grade inflammation. Adipokines bioactive peptides secreted by adipose tissue play a pivotal role in modulating glucose homeostasis, lipid...
2025 | IDOSR JOURNAL OF EXPERIMENTAL SCIENCES | Pp. 78-88
The global prevalence of obesity and type 2 diabetes mellitus (T2DM) continues to rise at an alarming rate, posing a major public health and economic challenge worldwide. Growing evidence indicates that the gut microbiota plays a crucial role in the developme...
2025 | IDOSR JOURNAL OF EXPERIMENTAL SCIENCES | Pp. 70-77
Obesity-driven type 2 diabetes is a multifactorial metabolic disorder in which dysfunctional inter-organ communication particularly between adipose tissue and skeletal muscle plays a pivotal role. Adipokines and myokines are hormone-like factors produced by a...
2025 | IDOSR JOURNAL OF EXPERIMENTAL SCIENCES | Pp. 59-69
Non-communicable diseases (NCDs), including obesity, diabetes, cardiovascular disease, cancer, and chronic respiratory disorders, are the leading global causes of morbidity and mortality. Recent advances in microbiome research have revealed its central role i...
2025 | IDOSR JOURNAL OF EXPERIMENTAL SCIENCES | Pp. 48-58
The human microbiome, composed of trillions of bacteria, archaea, fungi, and viruses, is essential for maintaining metabolic, immune, and neurological homeostasis. With aging, the composition and function of microbial communities undergo profound changes, con...
2025 | IDOSR JOURNAL OF EXPERIMENTAL SCIENCES | Pp. 39-47
Cancer immunotherapy has emerged as a powerful approach to harness the immune system to combat tumors, while cancer immunoprevention aims to elicit protective immunity before cancer onset. Nanovaccines engineered nanoparticles that deliver tumor-associated an...
2025 | IDOSR JOURNAL OF EXPERIMENTAL SCIENCES | Pp. 31-38
Obesity-induced type 2 diabetes mellitus (T2DM) is a growing global health concern driven by chronic lowgrade inflammation, insulin resistance, and impaired metabolic homeostasis. Conventional therapies such as lifestyle interventions, antidiabetic drugs, and...
2025 | IDOSR JOURNAL OF EXPERIMENTAL SCIENCES | Pp. 24-30
Obesity is a growing global epidemic, associated with diabetes, cardiovascular disease, cancer, and diminished life expectancy. Pharmacological treatments are often limited by poor bioavailability, low target specificity, and systemic toxicity. Nanotechnology...