Research outputs, reports, policy briefs and knowledge products from KIU scholars and partners.
Knowledge Outputs
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2025 | IDOSR JOURNAL OF EXPERIMENTAL SCIENCES | Pp. 17-23
The gut microbiome plays a pivotal role in obesity pathogenesis by influencing nutrient absorption, energy metabolism, inflammation, and host signaling pathways. Dysbiosis imbalances in microbial composition has been linked to weight gain, insulin resistance,...
2025 | IDOSR JOURNAL OF EXPERIMENTAL SCIENCES | Pp. 12-16
Artemisinin derivatives are the backbone of current malaria therapy, yet Plasmodium falciparum resistance threatens global control efforts. Poor solubility, short half-life, and suboptimal tissue distribution limit their efficacy. Nanoparticle encapsulation o...
2025 | IDOSR JOURNAL OF EXPERIMENTAL SCIENCES | Pp. 5-11
Diabetes mellitus affects over 537 million adults worldwide, with inadequate glycemic control contributing to significant morbidity and mortality despite advances in insulin therapy. Conventional insulin delivery systems faced limitations including frequent i...
2025 | IDOSR JOURNAL OF SCIENTIFIC RESEARCH | Pp. 128-135
Obesity profoundly alters insulin pharmacokinetics and pharmacodynamics through expanded and inflamed adipose depots, altered subcutaneous tissue architecture, and systemic low-grade inflammation, all of which complicate insulin replacement therapy. Nanoparti...
2025 | IDOSR JOURNAL OF SCIENTIFIC RESEARCH | Pp. 119-127
Cancer remains one of the leading causes of mortality worldwide, posing significant challenges to conventional therapeutic approaches due to poor targeting, systemic toxicity, and multidrug resistance. Nanoparticle-based drug delivery systems (NDDSs) have eme...
2025 | IDOSR JOURNAL OF EXPERIMENTAL SCIENCES | Pp. 1-4
Antiretroviral therapy (ART) had transformed HIV infection into a chronic, manageable condition. However, drug resistance, poor adherence, and limited drug penetration into viral reservoirs hinder long-term viral suppression and complicate cure strategies. No...
2025 | IDOSR JOURNAL OF SCIENTIFIC RESEARCH | Pp. 136-139
Malaria caused by Plasmodium falciparum remains one of the most pressing public health challenges in sub-Saharan Africa and Southeast Asia. Artemisinin-based combination therapies (ACTs) have reduced mortality substantially over the past two decades, yet part...
2025 | IDOSR JOURNAL OF SCIENTIFIC RESEARCH | Pp. 112-118
Obesity and metabolic syndrome are multifactorial conditions characterized by dysregulated energy metabolism, insulin resistance, chronic inflammation, and increased risk of diabetes and cardiovascular disease. Conventional pharmacological treatments often pr...
2025 | IDOSR JOURNAL OF SCIENTIFIC RESEARCH | Pp. 105-111
Obesity-driven type 2 diabetes (T2D) remains a major global health challenge. Activation or recruitment of thermogenic adipocytes classical brown adipose tissue (BAT) and inducible beige adipocytes within white adipose tissue (WAT) increases energy expenditur...
2025 | IDOSR JOURNAL OF SCIENTIFIC RESEARCH | Pp. 96-104
Diabetes mellitus remains one of the most pressing global health concerns, with type 1 and type 2 diabetes affecting millions of individuals worldwide. Conventional drug delivery methods often face challenges such as poor bioavailability, systemic side effect...