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2026 Faculty of Science and Technology

Neurotoxicity and Diabetes: Mechanistic Insights into Oxidative Stress Mediated Neuronal Damage and Potential Neuroprotective Interventions

Kato Jumba K.

2026 | IDOSR JOURNAL OF SCIENCE AND TECHNOLOGY | Pp. 61-66

Diabetes mellitus is associated with accelerated neuronal injury manifesting as diabetic peripheral neuropathy, cognitive impairment, and heightened risk of neurodegenerative disease. A large body of evidence implicates oxidative stress-the imbalance between...

2026 School of Natural and Applied Sciences

Neurotoxicity and Antioxidant Herbal Remedies: A Critical Appraisal of Evidence

Mugo Moses H.

2026 | IDOSR JOURNAL OF BIOCHEMISTRY, BIOTECHNOLOGY AND ALLIED FIELDS | Pp. 1-5

Neurotoxicity-injury to the nervous system resulting from chemical, biological, or physical insults-remains a pressing clinical and public-health problem across acute exposures (organophosphates, heavy metals, chemotherapeutics), chronic environmental polluti...

2026 School of Allied Health Sciences

Neuromodulatory Potential of Natural Antioxidants in Diabetic Neuropathy: Molecular Mechanisms and Therapeutic Insights

Alberta Jeanne N.

2026 | IDOSR JOURNAL OF BIOLOGY, CHEMISTRY AND PHARMACY | Pp. 37-41

Diabetic neuropathy is a common, debilitating complication of diabetes characterized by sensory loss, neuropathic pain, and autonomic dysfunction. Oxidative stress is a central pathogenic driver, promoting neuronal damage, mitochondrial dysfunction, and malad...

2026 School of Allied Health Sciences

Neuromodulation and Metabolic Detoxification: Natural Compounds as Mediators Between Environmental Toxicity and Neurodegenerative Risks in Diabetic Conditions

Fabiola Mwendwa G.

2026 | IDOSR JOURNAL OF BIOLOGY, CHEMISTRY AND PHARMACY | Pp. 52-56

Diabetes mellitus alters systemic metabolism and increases vulnerability to both environmental toxicants and neurodegenerative processes. Environmental chemicals-heavy metals, persistent organic pollutants, pesticides, and air pollutants-can exacerbate oxidat...

2026 School of Pharmacy

Nephrotoxicity and Herbal Interventions: Mechanistic Insights and Safety Concerns

Bwanbale Geoffrey David

2026 | IDOSR JOURNAL OF SCIENCE AND TECHNOLOGY | Pp. 56-60

Nephrotoxicity, defined as structural and functional impairment of the kidneys due to chemical, biological, or metabolic insults, is a significant contributor to global morbidity and mortality. It arises from diverse causes including pharmaceutical agents, he...

2026 Faculty of Science and Technology

Natural Product-Based Neuromodulators in the Prevention of Diabetic Anaemia: Linking Antioxidant Defense to Erythroid and Neural Function

Nyakairu Doreen G.

2026 | IDOSR JOURNAL OF BIOLOGY, CHEMISTRY AND PHARMACY | Pp. 67-71

Diabetic anemia is a common and often under-recognized complication of diabetes mellitus, characterized by impaired erythropoiesis, reduced erythropoietin production, and systemic oxidative stress. This condition not only compromises oxygen delivery to periph...

2026 Faculty of Science and Technology

Micro-and Nanoplastic-Induced Biochemical Toxicity: Emerging Mechanisms and Health Risks Across Biological Systems

Kibibi Muthoni L.

2026 | IDOSR JOURNAL OF BIOCHEMISTRY, BIOTECHNOLOGY AND ALLIED FIELDS | Pp. 21-25

Micro- and nanoplastics (MNPs) - particles derived from the fragmentation of larger plastic debris or manufactured intentionally at microscopic scales - are now ubiquitous across terrestrial, freshwater, marine, and atmospheric environments. Their small size,...

2026 School of Natural and Applied Sciences

Metabolic and Immune Toxicities of Common Therapies for Diabetes, BPH, and Autoimmune Conditions: A Comparative Review of Hepatic and Systemic Adverse Effects

Mwende Wairimu G.

2026 | IDOSR JOURNAL OF BIOCHEMISTRY, BIOTECHNOLOGY AND ALLIED FIELDS | Pp. 36-41

Chronic diseases such as type 2 diabetes mellitus, benign prostatic hyperplasia (BPH), and autoimmune disorders necessitate long-term pharmacotherapy, which can predispose patients to metabolic, hepatic, and immune toxicities. This review examines the compara...

2026 School of Allied Health Sciences

Interplay Between Oxidative Stress and Erythropoiesis in Diabetes: Emerging Roles of Neuromodulators and Natural Product Antioxidants in Anaemia Management

Fabiola Mwendwa G.

2026 | IDOSR JOURNAL OF BIOLOGY, CHEMISTRY AND PHARMACY | Pp. 47-51

Anaemia is a common and underappreciated complication of diabetes that worsens quality of life, increases cardiovascular risk, and accelerates progression of diabetic complications. Multiple interacting mechanisms contribute to diabetes-associated anaemia, in...

2026 Faculty of Science and Technology

Interplay Between Oxidative Stress and Antioxidant Defenses in the Pathogenesis and Management of Diabetes

Mellitus Mugisha Emmanuel K.

2026 | IDOSR JOURNAL OF SCIENCE AND TECHNOLOGY | Pp. 13-20

Diabetes mellitus is a global metabolic disorder characterized by chronic hyperglycaemia and an array of microvascular and macrovascular complications. A substantial body of evidence implicates oxidative stress-an imbalance between reactive oxygen species (RO...