Research outputs, reports, policy briefs and knowledge products from KIU scholars and partners.
Knowledge Outputs
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2026 | IDOSR JOURNAL OF BIOLOGY, CHEMISTRY AND PHARMACY | Pp. 111-117
Chronic immune activation represented a hallmark pathophysiological feature of both HIV infection and type 1 diabetes mellitus, characterized by persistent elevation of inflammatory cytokines, activated immune cell populations, and acute-phase reactants despi...
2026 | IDOSR JOURNAL OF BIOLOGY, CHEMISTRY AND PHARMACY | Pp. 106-110
Hypertensive disorders of pregnancy (HDP), encompassing gestational hypertension, pre-eclampsia, eclampsia, and chronic hypertension complicating pregnancy, remain a major contributor to maternal and perinatal morbidity and mortality in Nigeria. Despite estab...
2026 | IDOSR JOURNAL OF BIOLOGY, CHEMISTRY AND PHARMACY | Pp. 99-105
Human immunodeficiency virus type 1 (HIV-1) infection affected approximately 38 million individuals globally, with lifelong antiretroviral therapy required to suppress viral replication. Despite effective viral suppression, antiretroviral therapy does not era...
2026 | IDOSR JOURNAL OF BIOLOGY, CHEMISTRY AND PHARMACY | Pp. 85-92
Broadly neutralizing antibodies (bNAbs) against HIV-1 Env have redefined prospects for biomedical prevention, offering long-acting, mechanism-based protection complementary to antiretroviral pre-exposure prophylaxis (PrEP). This review synthesized recent mech...
2026 | IDOSR JOURNAL OF BIOLOGY, CHEMISTRY AND PHARMACY | Pp. 93-98
Human immunodeficiency virus continued to present a formidable global health challenge despite advances in antiretroviral therapy. Broadly neutralizing antibodies represent a unique class of immunoglobulins capable of recognizing conserved epitopes across div...
2026 | IDOSR JOURNAL OF BIOLOGY, CHEMISTRY AND PHARMACY | Pp. 78-84
Bariatric/metabolic surgery is the most effective intervention for achieving substantial and durable weight loss in people with obesity and has profound, often rapid, effects on glycemic control in type 2 diabetes (T2D). Beyond calorie restriction and weight...
2026 | IDOSR JOURNAL OF BIOLOGY, CHEMISTRY AND PHARMACY | Pp. 72-77
Diabetic patients in Nigeria are disproportionately affected by bacterial and fungal infections, with hyperglycemia, immune dysfunction, and comorbidities increasing susceptibility and complicating clinical outcomes. Common pathogens include Staphylococcus au...
2026 | IDOSR JOURNAL OF BIOLOGY, CHEMISTRY AND PHARMACY | Pp. 33-36
Climate variability, including extreme weather events such as floods and droughts, has significant implications for water contamination and the occurrence of waterborne diseases like typhoid fever. This review explores the mechanisms by which floods and droug...
2026 | IDOSR JOURNAL OF BIOLOGY, CHEMISTRY AND PHARMACY | Pp. 28-32
Artificial joint replacements, including hip and knee arthroplasties, are critical surgical interventions that significantly enhance mobility and quality of life for individuals suffering from degenerative or traumatic joint diseases. However, in West Africa,...
2026 | IDOSR JOURNAL OF BIOLOGY, CHEMISTRY AND PHARMACY | Pp. 8-14
Obesity and type 2 diabetes are heterogeneous, chronic disorders driven by complex genetic, behavioral and environmental factors, leading to widely variable responses to lifestyle and pharmacologic therapies. Conventional treatment paradigms rely on populatio...