Research outputs, reports, policy briefs and knowledge products from KIU scholars and partners.
Knowledge Outputs
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2026 | IDOSR JOURNAL OF BIOCHEMISTRY, BIOTECHNOLOGY AND ALLIED FIELDS | Pp. 16-20
Oxidative stress is a central pathological mechanism underlying diverse complications in metabolic and systemic disorders, including anaemia and neurotoxicity. Reactive oxygen and nitrogen species generated in excess can impair erythropoiesis, shorten red blo...
2026 | IDOSR JOURNAL OF BIOLOGY, CHEMISTRY AND PHARMACY | Pp. 62-66
The liver and brain are interconnected through a complex network known as the liver-brain axis, which plays a pivotal role in maintaining systemic homeostasis. Disruptions in this communication, due to environmental toxins or metabolic disorders, can lead to...
2026 | IDOSR JOURNAL OF SCIENCE AND TECHNOLOGY | Pp. 88-92
Benign prostatic hyperplasia (BPH) is a highly prevalent condition in aging men, historically attributed to androgenic and hormonal imbalances. However, mounting evidence supports a central role for the immune–prostate axis in its development. Chronic inflamm...
2026 | IDOSR JOURNAL OF BIOCHEMISTRY, BIOTECHNOLOGY AND ALLIED FIELDS | Pp. 42-46
The liver is the primary site for xenobiotic metabolism and detoxification, rendering it particularly vulnerable to injury from drugs, environmental toxicants, dietary chemicals, and industrial pollutants. Hepatotoxicity triggers complex interactions between...
2026 | IDOSR JOURNAL OF SCIENCE AND TECHNOLOGY | Pp. 103-108
Chronic metabolic diseases-particularly type 2 diabetes mellitus (T2DM) and the metabolic syndrome-are major drivers of contemporary liver morbidity, ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis and cirrhosis. Hepatotoxicity...
2026 | IDOSR JOURNAL OF SCIENCE AND TECHNOLOGY | Pp. 109-113
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia, insulin resistance, and impaired glucose homeostasis. Among its complications, liver dysfunction is common, often manifesting as nonalcoholic fatty liver disease...
2026 | IDOSR JOURNAL OF SCIENCE AND TECHNOLOGY | Pp. 51-55
Immune dysregulation arises from a complex interplay between genetic predisposition, environmental exposures, and dynamic epigenetic modifications that collectively shape immune cell development, signaling, and responsiveness. Over the past two decades, rapid...
2026 | IDOSR JOURNAL OF BIOLOGY, CHEMISTRY AND PHARMACY | Pp. 57-61
The liver-brain axis represents a complex and dynamic interface where hepatic metabolic processes influence central nervous system (CNS) function, and conversely, neural and neuroendocrine signals modulate liver physiology. This bidirectional communication is...
2026 | IDOSR JOURNAL OF BIOLOGY, CHEMISTRY AND PHARMACY | Pp. 42-46
Environmental toxicants from industrial pollutants and agrochemicals to heavy metals and mycotoxins are pervasive contributors to liver injury worldwide. The liver’s central role in xenobiotic metabolism renders it particularly vulnerable: biotransformation r...
2026 | IDOSR JOURNAL OF BIOCHEMISTRY, BIOTECHNOLOGY AND ALLIED FIELDS | Pp. 31-35
Endocrine-disrupting chemicals (EDCs) are widespread environmental contaminants capable of mimicking, antagonizing, or altering endogenous hormone signaling. Beyond classical toxicological endpoints, a growing body of evidence shows that EDCs induce epigeneti...