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Title: | Evaluation of Musa acuminata Starch as a Diluent in Paracetamol Tablet Formulations |
Author(s): | Tansah Mbunwe |
Year | 2024 |
Publisher: | IDOSR JOURNAL OF BIOCHEMISTRY, BIOTECHNOLOGY AND ALLIED FIELDS |
URI: | https://kiu.ac.ug/publication-page.php?i=evaluation-of-musa-acuminata-starch-as-a-diluent-in-paracetamol-tablet-formulations |
File: | |
Keywords: |
Tablet formulation, a widely used dosage form, relies on excipients like diluents to ensure product quality. This
study investigates the potential of Musa acuminata (matoke banana) starch as a diluent in paracetamol tablets.
Starch was extracted from matoke bananas and formulated into three batches using wet granulation, with
concentrations of 5%, 10%, and 15% w/w. Comparative analysis was conducted with maize starch. Physiochemical
properties of starch and granules, as well as tablet characteristics, were evaluated. Results indicated comparable
properties between matoke and maize starches. Tablets formulated with matoke starch exhibited optimal
disintegration time, hardness, friability, and weight uniformity, suggesting its potential as a cost-effective and
accessible alternative diluent
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