This study aimed to assess young adults' knowledge and practices that affect safe sex behavior among university students
in Uganda, with a particular focus on Kampala International University Western Campus. The study was conducted at the
university's Western Campus, involving medical students aged 19-25. The sample size was 249. The study used Raosoft's
online sample size calculator and simple random sampling techniques to obtain respondents. Data collection involved selfadministered
questionnaires consisting of 29 closed-ended questions. The study found a negative relationship between
socio-economic and demographic factors and safe sex behaviors among young adults at Kampala International University.
However, the relationship between socio-demographic factors and safe sex behaviors was not statistically significant. The
findings revealed a positive and significant relationship between knowledge, practice and safe sex behaviors among young
adults at Kampala International University Western Campus. Recommendations include providing comprehensive sex
education to all young adults at Kampala International University to enable them to learn about sexuality and the risks
associated with it. Comprehensive sex education should be holistic, incorporating age-appropriate and culturally
appropriate information about reducing the risk of being sexually unsafe.
Keywords: Safe sex, young adult, university students, questionnaire, Uganda